MEDICATIONS

Topiramate

Topiramate is a medication that reduces appetite and is used in combination with phentermine (Qsymia) for chronic weight management, achieving 8–10% body weight reduction.

Topiramate is a medication originally developed for epilepsy and migraines that has been found to help with weight loss. It works by reducing appetite and making food taste less appealing, helping you eat less without feeling deprived.

Topiramate is a sulphamate-substituted monosaccharide anticonvulsant that promotes weight loss through multiple mechanisms: carbonic anhydrase inhibition, glutamate receptor (AMPA/kainate) antagonism, and GABA-A receptor potentiation. It is approved in combination with phentermine (Qsymia) for chronic weight management, demonstrating 8–10% mean body weight reduction in clinical trials.

As a component of combination pharmacotherapy (Qsymia), topiramate offers an effective option for patients who have not achieved sufficient weight loss with lifestyle modification alone. Its unique mechanism complements other weight loss medications, allowing for personalised treatment strategies under medical supervision.

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Medical Disclaimer

This library is for general education and does not replace individual assessment by a qualified healthcare professional. Always consult a doctor for medical advice, diagnosis, or treatment.

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