Patient-Friendly Explanation

Peptide YY, or PYY, is a hormone released by your gut after eating. It sends signals to your brain telling you that you are full, helping to naturally reduce your appetite and food intake.

Clinical Definition

Peptide YY is a 36-amino acid anorexigenic hormone secreted by L-cells in the distal ileum and colon in proportion to caloric intake. PYY3-36, the active form, binds to Y2 receptors in the arcuate nucleus of the hypothalamus, inhibiting neuropeptide Y (NPY) release and reducing appetite.

Why It Matters

Understanding PYY helps explain why certain weight loss strategies, such as high-protein meals and GLP-1 receptor agonists, promote satiety. At NuLifeCare Singapore, our medical weight management programme leverages this science to develop sustainable, appetite-regulating treatment plans.