Patient-Friendly Explanation

A skin condition causing dark, velvety patches in body folds like the neck, armpits, or groin. It is often a visible sign of insulin resistance and can indicate a higher risk of developing type 2 diabetes. Weight loss can help improve or reverse these skin changes.

Clinical Definition

Acanthosis nigricans is a dermatological manifestation characterised by hyperpigmented, hyperkeratotic plaques in intertriginous areas. It is strongly associated with hyperinsulinaemia and insulin resistance, where elevated circulating insulin stimulates keratinocyte and dermal fibroblast proliferation via IGF-1 receptor activation.

Why It Matters

Early recognition allows for timely metabolic screening. At NuLifeCare Singapore, we address the root cause through medical weight management that improves insulin sensitivity and often resolves skin changes.