CONDITIONS

Depression and Weight

Depression and obesity share a bidirectional relationship — effective weight management requires addressing both mental and physical health.

Depression and weight problems often go hand in hand. Low mood can lead to overeating, reduced activity, and poor sleep, while struggling with weight can worsen self-esteem and emotional wellbeing. Addressing both together gives the best results.

The relationship between depression and obesity is bidirectional, mediated by hypothalamic-pituitary-adrenal (HPA) axis dysregulation, chronic low-grade inflammation, and behavioural factors including emotional eating and reduced physical activity. Certain antidepressants, particularly SSRIs and tricyclics, can also cause clinically significant weight gain, requiring careful medication selection in patients with comorbid obesity.

Effective weight management programmes must consider mental health alongside physical health — sustainable outcomes depend on addressing both dimensions of wellbeing.

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Medical Disclaimer

This library is for general education and does not replace individual assessment by a qualified healthcare professional. Always consult a doctor for medical advice, diagnosis, or treatment.

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