MEDICATIONS

Tesofensine

An investigational triple reuptake inhibitor that suppresses appetite by increasing serotonin, noradrenaline, and dopamine in the brain.

Tesofensine is an investigational weight-loss medication that works by increasing the levels of three brain chemicals — serotonin, noradrenaline, and dopamine — that control appetite and metabolism. Originally studied for neurological conditions, it was found to produce significant weight loss as a side effect, leading to its development as an obesity treatment.

Tesofensine is a triple monoamine reuptake inhibitor that blocks the presynaptic reuptake of serotonin, noradrenaline, and dopamine. By elevating synaptic levels of all three neurotransmitters, it suppresses appetite and increases energy expenditure. Phase II trials demonstrated dose-dependent weight loss exceeding 10% of baseline body weight over 24 weeks, with the 0.5 mg dose showing a favourable benefit-risk profile. Phase III trials are underway to confirm long-term safety and efficacy.

Tesofensine represents a different mechanism from the GLP-1 class that dominates current obesity pharmacotherapy. For patients who do not respond adequately to or cannot tolerate GLP-1 agonists, drugs like tesofensine could offer a valuable alternative pathway. NuLifeCare Singapore monitors emerging therapies to provide patients with the widest evidence-based options.

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Medical Disclaimer

This library is for general education and does not replace individual assessment by a qualified healthcare professional. Always consult a doctor for medical advice, diagnosis, or treatment.

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